CURRICULUM VITAE

Name: Muhammer Ozgur
Surname: CEVIK
Address: 1) Adıyaman University School of Medicine
Department of Medical Genetics Atatürk Bulvarı No:1 02040 Adıyaman Turkey 
E-mail: mogcev@gmail.com , ocevik@adiyaman.edu.tr

Personal Information:

Nationality: Turkey,
Date of Birth: 1978
Place of Birth: Ankara, Turkey

Current Position

Assistant Professor, Department of Medical Genetics, Faculty of Medicine, Adiyaman University, 02040, Adiyaman-Turkey.

International Experience:

Japan: April 2004- April 2009, Kyoto Prefectural Medical School, Department of Pharmacology, Kyoto, as a PhD student (Full scholarship holder from Japanese Ministry of Education and Sports-Monbusho for 5 years).
Czech Republic: June 2010-July 2010, Charles University, Medical School, Department of Molecular Biology, as a visiting observer scientist.

USA: November 2011-February 2012, Medical University of South Carolina, John Hopkins Cancer Center, Department of Molecular Biology and Biochemistry, Charleston, South Carolina, as a visiting scientist.
USA: Harvard University School of Medicine Department of Genetics and Boston Children’s Hospital Department of Ortopaedic Research 2015 November-now.

Awards:

1) The Scientific and Technological Research Council of Turkey Scholarship Award for Postdoctoral Research at Harvard University (2015-2016)
2) Turkish Higher Education Council (YOK) Scholarship award for Research in USA (November 2011- February 2012, three months) 3) Japanese Ministry of Education, Culture, Sports, Science and Technology (MOMBUSHO) scholarship covering full tuition and life expenses for PhD for 5 years (2004-2009).

4) Adiyaman University Scientific Achievement Award (years 2010 and 2013).

Educational Background in Brief

Academic Experience in Brief

Full Text Publications in International Journals:

1) Myocyte enhancer factor 2B is involved in the inducible expression of NOX1/NADPH oxidase, a vascular
superoxide- producing enzyme. FEBS J. 2007 Oct; 274(19):5128-36.
Authors: Masato Katsuyama*, Muhammer Ozgur Cevik*, Noriaki Arakawa, Tomoko Kakehi, Toru Nishinaka, Kazumi Iwata, Masakazu Ibi, Kuniharu Matsuno and Chihiro Yabe-Nishimura . * Equal contributor

2) The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme: Possible involvement of the ERK1/2-JunB pathway. Biochem Biophys Res Commun. 2008 Jul 15; 18638447.
Authors: Muhammer Ozgur Cevik, Masato Katsuyama, Sayaka Kanda, Tetsuo Kaneko, Kazumi Iwata, Masakazu Ibi, Kuniharu Matsuno, Tomoko Kakehi, Wenhao Cui, Mika Sasaki, Chihiro Yabe-Nishimura.

3) CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells. Int J Oncol. 2008 May; 32(5): 1105-10.

Authors: Koichi Takagi, Yoshihiro Sowa, Ozgur Muhammer Cevik, Ryoko Nakanishi and Toshiyuki Sakai.
4) Is there a relationship between Toxoplasma gondii infection and idiopathic Parkinson's disease? Scand J Infect Dis. 2010Apr 9.

Authors: Celik T, Kamisli O, Babür C, Cevik MO, Oztuna D, Altinayar S.

5) Off-Target Function of the Sonic-Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide-Dependent Neutral Sphingomyelinase 2/Ceramide Induction. Mol Cancer Ther. 2012 Mar 27. Authors: Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, Martins da Palma TR, Nishimura MI, Kraveka J, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B.

6) Thr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease (BD). Peptides. 2013 Apr; 42:97-100.
Authors: Oztuzcu S, Ulasli M, Pehlivan Y, Cevik MÖ, Cengiz B, Gogebakan B, Igci YZ, Okumuş S, Arslan A, Onat AM.

7) Screening of common and novel familial mediterranean fever mutations in south-east part of Turkey. Mol Biol Rep. 2014 Apr;41(4):2601-7
Authors: Oztuzcu S1, Ulaşlı M, Ergun S, Iğci YZ, Iğci M, Bayraktar R, Nacarkahya G, Tamer A, Cevik MO, Cakmak EA, Arslan A.

8) The role of the UTS2 gene polymorphisms and plasma Urotensin-II levels in breast cancer. Tumor Biol. 2015 Jun;36(6):4427- 32. doi: 10.1007/s13277-015-3082-2.
Authors: Onder Yumrutas, Serdar Oztuzcu, Hakan Büyükhatipoglu, Ibrahim Bozgeyik, Esra Bozgeyik, Yusuf Ziya Igci, Haydar Bagis, M. Ozgur Cevik, M. Emin Kalender, Zeynep Eslik, Ahmet Arslan.

9) Cell viability, anti-proliferation and antioxidant activities of Sideritis syriaca, Tanacetum argenteum subsp. argenteum and Achillea aleppica subsp. zederbaueri on human breast cancer cell line (MCF-7). J App Pharm Sci. 2015; 5(3): 001-005. Authors: Onder Yumrutas · Serdar Oztuzcu, Mustafa Pehlivan, Nilgun Ozturk, I. Poyraz, Yusuf Igci, M. Cevik, Ibrahim Bozgeyik, Ayse Aksoy, Haydar Bagis, Ahmet Arslan

10) Is there a relationship between low vitamin D levels and rotaviral diarrhea? Pediatr Int. 2015 Aug 19. doi: 10.1111/ped.12809. Authors: Bucak IH, Alm Ş H, Çevik MÖ, Bülbül M, Tekin M, Konca Ç, Turgut M, Öztürk AB.

11) Possible relation of antenatal venlafaxine use and VACTERL association in a newborn: A Case Report. Turkish Journal of Psychiatry 2015. Case Study 10.5080/u13515. Authors: Muammer Özgür ÇEVİK, Mustafa ÇELİK, İbrahim Hakan BUCAK, Behice HAN ALMİS, Mehmet TURĞUT.

12) Disappearing inferior vena cava in a pediatric patient with Down Syndrome and hereditary thrombophilia. Journal of the Belgian Society of Radiology, 100(1): 22, pp. 1–4, DOI: http://dx.doi.org/10.5334/jbr-btr.975. Authors: Bulent Petik, Muhammer Ozgur Cevik, Mehmet Sirik, Deniz Colak and Sukru Mehmet Erturk.

Poster Presentations in International Scientific Meetings:

Neuropeptide-Y decreases cortex and bone marrow density in a dose dependent manner without mechanical strength changes. 53rd Annual Meeting of the Orthopedic Research Society, February
2007. Authors: M.O Cevik, F Korkusuz, A Senkoylu, P Korkusuz

Quercetin suppresses induction of NOX1/NADPH oxidase expression in vascular smooth muscle cells. 81st Annual Meeting of the Japanese-Pharmacological-Society, Yokohama, JAPAN, MAR 17-19, 2008.
Authors: Katsuyama M (Katsuyama, Masato), Cevik MO (Cevik, Muhamer-Ozgur), Kanda S (Kanda, Sayaka), Kaneko T (Kaneko, Tetsuo), Dokan R (Dokan, Rumiko), Yabe-Nishimura C (Yabe-Nishimura, Chihiro)

The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme: Possible involvement of the ERK1/2-JunB pathway. 775th Meeting of Kyoto Prefectural School of Medicine Scientific Society, Kyoto, Japan, 2009, October 16th. J. Kyoto Pref. Univ. Med., 2009 January, 118 (1).
Authors: CEVIK, Muhammer Ozgur, Katsuyama Masato, Nishimura Chihiro Yabe.

Chrysin induces apoptosis independent of caspases in SW480 colon adenocarcinoma cells. 3rd International Congress on Nutrition and Cancer, Bodrum, Mugla, TURKEY, OCT 20-24,
2010. Authors: Cevik, Muhammer Ozgur

Expression of human NADPH oxidase 1 (NOX1) protein’s c-terminal portion in bulk lysate in E.coli BL21(DE23) with pMAL vector expression system. European Biotechnology Congress, Sept 28- Oct 1, 2011. Abstracts/ Current Opinion in Biotechnology, 22S, 2011 September, Volume 22, supplement 1, page 117.
Authors: Cevik, Muhammer Ozgur

Diosmetin, a natural flavonoid found in fruits and vegetables, is toxic to HT-29 colon adenocarcinoma cells. 4th International Congress on Nutrition and Cancer, Antalya, TURKEY, OCT 19-23, 2011.
Authors: Cevik, Muhammer Ozgur

Antiproliferative, Apoptotic and Necrotic Effects Mentha longifolia (L). Hudson subsp typhoides (Briq) var. Typhoides on A549 Lung Cancer Cells. 9th International Anti-Cancer Congress, Athens, Greece, 2014.
Authors: Yumrutas O, Oztuzcu S, Pehlivan M, Ulasli M, Sokmen M, Bozgeyik I, Temiz E, Cevik MO, Dagli H, Arslan A.

Screening of Common and Novel Familial Mediterranean Fever Mutations in South-East Part of Turkey. 25th Annual Meeting of the German Society of Human genetics, 148; 03/2014.

Authors: Serdar Öztuzcu, Mustafa Ulaşlı, Sercan Ergün, Yusuf Ziya İğci, Mehri İğci, Recep Bayraktar, Gülper Nacarkahya, Ali Tamer, Muammer Özgür Çevik, Ecir Ali Çakmak, Ahmet Arslan.

Effect of walnut supplements on lipid metabolism in a high-fat diet-fed animal model.Clin Chem Lab Med 2014; 52, Special Suppl, pp S1 – S1760, June 2014. IFCC WorldLab Istanbul 2014 –DOI 10.1515/cclm-2014-4040.
Authors: S. Yilmaz, B. Aydinol, M. O.Çevik, A. Arpacı, M. Önderci, İ. Toktaş. 2014.

Isolation and Characterization of Cancer Stem Cell in Glioma.. The 18th Takeda Science Foundation Symposium on Bioscience "iPS Cells for Regenerative Medicine" "CiRA International Symposium", Osaka, Japan; 01/15/2015
Authors: Omer Faruk Hatipoglu, Murat Oznur, Esin Demir, Onur Bender, Muradiye Acar, Burak Yilmaz, M.Ozgur Cevik, Esra Gunduz, Mehmet Gunduz

Evaluation of apoptosis, cell cycle, DNA fragmentation, cell viability and cellular antioxidant potential of Stachys rupestris on HeLa cancer cells. EACR-Sponsored 3rd Anticancer Agent Development Congress; 05/2015
Authors: Onder Yumrutas · Serdar Oztuzcu · Mustafa Pehlivan · Esra Bozgeyik · Ebru Temiz · Fatih Uckardes · Ibrahim Bozgeyik · Münevver Sokmen · M. Ozgur Cevik · Ahmet Arslan

Medicinal plant Nepeta cilicica which consitutes phenolic acids strongly induces the apoptosis of Lung and Breast cancer cells and exhibits powerful cellular antioxidant activities. EACR-Sponsored 3rd Anticancer Agent Development Congress; 05/2015. Authors:Onder Yumrutas · Serdar Oztuzcu · Mustafa Pehlivan · Ibrahim Bozgeyik · Munevver Sokmen · Ebru Temiz · Pınar Gökçek · Esra Bozgeyik · M. Ozgur Cevik · Hasan Dagli · Ahmet Arslan

Anticancer activities of apolar-semipolar-polar extracts of Thymus syriacus on breast cancer cell lines. EACR-Sponsored 3rd Anticancer Agent Development Congress; 05/2015.
Authors: Onder Yumrutas · Serdar Oztuzcu · Esra Bozgeyik · Mustafa Pehlivan · Munevver Sokmen Ibrahim Bozgeyik · Ebru Temiz · M. Ozgur Cevik · Pınar Gokcek · Hasan Dagli · Ahmet Arslan.

Induction of apoptosis in prostate cancer after treatment of apolar-semipolar-polar extracts of stachys pimula. EACR-Sponsored 3rd Anticancer Agent Development Congress; 05/2015.
Authors: Onder Yumrutas · Serdar Oztuzcu · Ibrahim Bozgeyik · Mustafa Pehlivan · Munevver Sokmen · Ebru Temiz · Esra Bozgeyik · M. Ozgur Cevik · Hasan Dagli · Ahmet Arslan

Novel mutation in COL1A1 gene in a Turkish boy with osteogenesis imperfekta? 12th International Skeletal Dysplasia Society Meeting, Istanbul, Turkey • July29,-August 1, 2015.
Authors: Muhammer Ozgur Cevik, Ilker Guney, Bulent Petik, Abuzer Uludag, Haydar Bagis


Clinical, cytogenetic and molecular evaluation of a phenotipically male patient with a karyotype of 46, XX but bearing an intact SRY loci: a case report. ASHG 2015 Annual Meeting in Baltimore, Maryland, October 6-10.
Authors: H. BAGIS, M.O. CEVIK, A. CIFT, I. GUNEY

Bilateral aniridia due to de novo deletion in 11p.1-p13 region may have resulted from HPV infection. ASHG 2015 Annual Meeting in Baltimore, Maryland, October 6-10.
Authors: S.G. Cevik , M.O. Cevik

Genetic counselling in a wound care unit: Unexpected contribution to conventional diagnosis strategies by drawing a pedigree to diagnose hereditary sensory and autonomic neuropathy type 2 (HSAN2) in female patient .
Authors: M.O CEVIK, F. DOGAN

Undergraduate and Graduate Courses Taught:

Laboratory Skills Acquired:

Basic molecular biology skills including cell culture, western blotting, northern blotting, DNA and RNA isolation, electrophoresis, PCR and RT- PCR, RNAi. MTT and WST8 cell toxicity tests, flow cytometric measurements of apoptosis, reactive oxygen species, mitochondrial membrane potential.
Protein expression methods in E.coli and its soluble recovery.

Memberships to Scientific Communities:

Turkish Society of Medical Genetics
Turkish Society of Medical Biology and Genetics Turkish Society of Biochemistry
EACR- European Association for Cancer Research Japanese Society of Pharmacology
The International Skeletal Dysplasia Society American Society of Human Genetics

Academic-Executive Duties:

Adıyaman University School of Medicine Executive Board Founder Member (2010-2011).
Adıyaman University School of Medicine Erasmus International Exchange Program Faculty Coordinator (2011-present). Adıyaman University Library and Documentation Center School of Medicine Contact Coordinator (2011-present). Turkish Ministry of Health Adiyaman Province Administration of Public Health Council of Mother and Child Deaths’ Investigation and Prevention (2013-present)

Language Skills

English: IELTS 8.5 Advanced level. Japanese: Advanced level. German:Intermediate
Turkish: Native.

Non-Technical Interests, Hobbies:

1) History, archeology, art, folklore and music of Asia Minor (Anatolia) of which were acquired while working as a professional tourist guide (in Japanese and in English) in Turkey.
2) Everything about Japan and Japanese culture.